Recently, omega-3 fatty acids are very popular among athletes. The main reason for this is their role in regulating immunity and their anti-inflammatory effect. Systemic and heavy sports have a negative effect on the immune system, and insufficient intake of omega-3 and excessive use of omega 6 essential fatty acids is a sure bomb with a delay. Omega-3s also have a number of proven health benefits for the human body, making them suitable for use by children, adults and pregnant women.
Table of Contents
What are omega-3 fatty acids?
Omega-3 fatty acids are a group of nine polyunsaturated fatty acids. The most important for human nutrition are three of them:
- Alpha linolenic acid (ALA);
- Eicosapentaenoic acid (EPA);
- Docosahexaenoic acid (DHA).
What the three fatty acids have in common, which separates them into a group, is the double carbon bond at the ω-3 (omega-3) position in their molecular structure.
- participate in the structure / composition of cell and nuclear membranes of cells;
- regulate and guarantee many functions of the immune system together with omega 6;
- have an irreplaceable role in the regulation of inflammatory processes and recovery;
- serve as donors of signaling molecules and thus participate in the processes of communication between the cells of the nervous system.
Omega-3s have several whole molecules in the body. These are GRP120 (free fatty acid receptor), AMPK (adenosine monophosphate kinase) and PPAR (peroxisome proliferator-activated receptor).
Proven and potential properties of omega-3 and fish oil
Proven impacts:
- EPA and DHA reduce blood triglycerides by between 15 and 30%;
- Fish oil successfully counteracts mild depression. The effect is comparable to the drug fluoxetine. The effect on bipolar disorder is similar. Significant benefits are found, but only in mild and advanced conditions;
- Improves mood, general well-being, suppresses anxiety and regulates aggression;
- Improves blood flow to the brain;
- Over 300 mg of DHA per day successfully regulates the symptoms of Attention Deficit Hyperactivity Disorder (ADHD);
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Lowers blood pressure, but only in people with high blood pressure;
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Increases “good” cholesterol in people with health problems;
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Mixed effect on “bad” cholesterol. It can lower it in healthy people, but also increase it in people with heart problems by 5-10%;
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Suppresses the symptoms of systemic lupus erythematosus between 30 and 50%;
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Lowers cortisol;
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Increases the reaction and improves the function of blood vessels;
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Significantly improves the weight of newborns when taken by the mother during pregnancy. Reduces the risk of death in newborns;
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Increases and regulates lipid peroxidation. It usually increases it in the presence of a stress factor, such as running a marathon;
- Provides protection from the sun’s rays. Reduces DNA damage and the immune system’s response. High doses of EPA protect skin color and reduce sunburn .;
- High doses of DHA (900 mg) help maintain mental state in the elderly;
- Increases ketone bodies in the body when combined with a proper diet;
Assumptions and unproven claims:
- Increases levels of growth hormone, including stimulating muscle growth;
- Possible reduction of platelets in the blood;
- Possible suppression of tumor necrosis factor alpha activity;
- It affects insulin sensitivity, but it is not clear to what extent. The results are mixed;
- Potential increase in HbA1c levels;
- One study confirmed a reduction in muscle fatigue. More research is needed;
- Pain suppression in people suffering from rheumatoid arthritis, anti-inflammatory action. Data for mixed. It may have an anti-inflammatory effect, mainly due to its immunosuppressive properties;
- Preventive effect in cancerous neoplasms, more precisely prevent the occurrence of cancer of the breast, colon and prostate; Potential homocysteine lowering effect;
- Potential effect on lowering liver fat;
- Possible improvements in memory and response time;
- Effects on blood sugar and insulin. It has not been proven at this stage;
- Weak effect on C-reactive protein. There is no statistical value;
- No direct effect on weight and fat burning has been found;
Proven properties |
Potential / Unproven | Rejected properties |
Triglycerides Platelets |
in the blood | Metabolism |
Mild depression | Growth hormone | Bone mineral density |
Mild states of bipolar disorder | HbA1c | Testosterone |
Anxiety and aggression | Insulin sensitivity | Sex hormone binding globulin (SHBG) |
Mood and well-being | Tumor necrosis factor alpha | Muscle damage |
Attention Deficit Hyperactivity Disorder (ADHD) | Muscle Fatigue | Liver Enzymes |
Blood supply to the brain | Rheumatoid arthritis Leptin | Leptin |
Blood pressure in the presence of high levels | Anti-cancer effect in breast, colon and prostate cancer | Muscle mass |
Lowers LDL in healthy people | Homocysteine | Proinflammatory cytokines |
Increases HDL in sick people | Liver fat | Heart rate |
Systemic lupus erythematosus | Memory | Fatigue |
Cortisol | response time | DHEA |
Blood vessel function | Blood sugar | Adiponectin |
Photoprotection | Insulin | |
Lipid peroxidation | C-reactive protein | |
Reduces the risk of death and increases weight in newborns | Burning fat | |
Mental state in the elderly | ||
Formation of ketone bodies |
Side effects and contraindications
The risks of omega-3 consumption are of two types:
- exceeding the recommended amounts of omega-3, which leads to an imbalance of omega-3: omega 6 EMF;
- insufficient intake of omega 6;
Including:
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Consumption of higher than normal doses of omega-3 can lead to increased bleeding in case of injury or even temporary inability to clot. Consumption of anticoagulants, such as aspirin, may increase the risk;
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Statistics show cases in which overuse of omega-3 for a long time is the most likely cause of the so-called. Hemorrhagic stroke (stroke type);
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Suppresses the immune response, as a result of which the consumer becomes more susceptible to infections and bacteria;
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Increases the levels of bad cholesterol in people with certain genetic predispositions.
Consumption of fish oil can also lead to some typical side effects, such as nausea, stomach irritation, upset or bad taste of fish in the mouth. They usually occur at high doses. There is a theory that high doses of fish oil in the elderly can increase DNA damage, which is directly related to lipid oxidation. So far, however, most of the scientific basis does not confirm these claims.
The main risk in consuming omega-3 products does not come from the omega-3s themselves, but from the quality of the fish oil. It is a known fact that fish oil can be a source of mercury, dioxins and PCBs (polychlorinated biphenyls). These substances can get into the oil through the source fish. Mercury is especially dangerous for the fetus of a pregnant woman because it can cross the placenta. Mercury is easy to digest in the human body and can last up to 75-90 days.
According to tests, the cleanest fish in terms of pollution are those that live in cold water and are not predators (mackerel, cod, sardines). The wing is also of high purity.
Attention!
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Reduces glycemic control in diabetics;
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They should not be taken without a prescription from people with heart failure or chronic angina.
Omega-3s do not show significant side effects per se. The greatest risk is associated with the consumption of contaminated fish oil.
Method of administration and optimal doses
Concomitant consumption of antioxidants and omega-3 mutually reduces the effectiveness of supplements. Leave a few hours interval between different supplements. The Stayfitlonger – Team recommends taking omega-3 with food. Breakfast or dinner is a good time to eat. The entire daily dose can be consumed at once. According to most sources, the permissible daily dose for omega-3 (EPA + DHA) is about 3 grams (3000 mg.), And the acceptable daily dose is 1.6 g for men and 1.1 g for women. (Food and Drug Administration, USA;).
According to the American Heart Association, the recommended daily dose is 1000 mg of omega-3 fatty acids. For a more pronounced anti-inflammatory effect, a daily dose of 6 grams is recommended. Pregnant women should get at least 200 mg of DHA a day. Because omega-3s are a fraction of the fats Alpha Linolenic Acid (ALA), Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA), and EPA and DHA have times higher physiological potency than ALA, we must also focus on their ratio in the given formula. It is considered that the ratio between ALA: (DHA + EPA) = 9: 1, i.e. the total amount of DKH and EPA should be about 10% of the total amount of omega-3 essential fatty acids.
It is good to take omega-3 and fish oil with food and other fatty acids, such as omega 6. It is advisable to avoid strong antioxidants around their intake.
In which supplements can we find Omega-3?
Omega-3 can most often be obtained from different types of oil. The most popular sources according to the bioactivity of omega-3 fatty acids are:
- Krill oil;
- Cod liver oil;
- Fish oil (anchovies, mackerel);
- Linseed oil.
The most affordable source is fish oil from more common fish such as anchovies, tuna, sardines and mackerel. The standard ratio of EPA to DHA is 180 mg to 120 mg per gram of oil (30% omega-3). There are also concentrated formulas such as Pure Nutrition Fish Oil (60%) and NOW Foods Ultra Omega-3 (75%). Flaxseed oil is a plant source of omega-3, but ALA has extremely low bioactivity. That is why the team of BB-Team Magazine recommends the use of fish oil as the main source of omega-3 fatty acids.
There are also combined formulas that combine omega-3, omega-6 and omega-9 fatty acids. In most cases, plant sources are used for all three types of fatty acids. Last but not least, omega-3s can be found in some complex formulas. Pure Nutrition Power Pak contains 1000 mg of fish oil per dose, and Universal Animal Flex includes flaxseed oil in its formula.
The most popular and affordable source of omega-3 is fish oil from popular fish such as mackerel, anchovies, sardines. Krill oil is considered to be the highest class product.
With what to combine omega-3 fatty acids?
Omega-3 is a basic food supplement for general health and can be combined with other similar food supplements and especially with those that are most deficient. Among the most popular combinations are omega-3 with vitamin D, zinc and magnesium. Due to the antioxidant properties of zinc, a distance between the intake of the two types of substances is recommended.
For anti-inflammatory effect, fish oil can be combined with curcumin and boswellia. To improve carbohydrate metabolism, the combination with taurine (synergistic effect), creatine, vitamin D and zinc is appropriate. Omega-3s show synergistic properties with astaxanthin in a healthy plan. In this regard, krill oil, which contains both substances, has an advantage.
The Stayfitlonger-Team recommends taking omega-3 and fish oil with other essential micronutrients. Vitamin D is our first choice!
You can read more about fish oil and omega-3 in:
- The link between omega-3 and children’s growth;
- Fish oil and its effect on the liver;
- Krill oil;
- Fish or linseed oil?
Sources used:
- Angerer P, von Schacky C. n-3 polyunsaturated fatty acids and the cardiovascular system. Curr Opin Lipidol. 2000 Feb;11(1):57-63.
- Charnock JS. Omega-3 polyunsaturated fatty acids and ventricular fibrillation: the possible involvement of eicosanoids. Prostaglandins Leukot Essent Fatty Acids. 1999 Oct;61(4):243-7.
- Connor WE. Importance of n-3 fatty acids in health and disease. Am J Clin Nutr. 2000 Jan;71(1 Suppl):171S-5S.
- Miller M. Current perspectives on the management of hypertriglyceridemia. Am Heart J. 2000 Aug;140(2):232-40.
- Simopoulos AP. Essential fatty acids in health and chronic disease. Am J Clin Nutr. 1999 Sep;70(3 Suppl):560S-569S.
- Kimura Y, et al. PUFAs in serum cholesterol ester and oxidative DNA damage in Japanese men and women. Am J Clin Nutr. (2012)
- Shoji H, et al. Effect of docosahexaenoic acid and eicosapentaenoic acid supplementation on oxidative stress levels during pregnancy. Free Radic Res. (2006)
- Tsuji M, et al. Relationship between RBC mercury levels and serum n3 polyunsaturated fatty acid concentrations among Japanese men and women. J Environ Public Health. (2012)
- Choi AL, et al. Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men. Environ Health Perspect. (2009)
- Mikami N, Hosokawa M, Miyashita K. Dietary combination of fish oil and taurine decreases fat accumulation and ameliorates blood glucose levels in type 2 diabetic/obese KK-A(y) mice. J Food Sci. (2012)
- Examine.com, 44 Studies related to Triglycerides and Fish Oil;
- Examine.com, 23 Studies related to Depression and Fish Oil;
- Omega-3 fatty acid treatment of children with attention-deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled study. Bélanger SA1, Vanasse M, Spahis S, Sylvestre MP, Lippé S, L’heureux F, Ghadirian P, Vanasse CM, Levy E.
- Effects of a small quantity of omega-3 fatty acids on cardiovascular risk factors in NIDDM. A randomized, prospective, double-blind, controlled study. Axelrod L1, Camuso J, Williams E, Kleinman K, Briones E, Schoenfeld D.
- Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. Wei MY1, Jacobson TA.
- The effects of eicosapentaenoic acid-fortified food on inflammatory markers in healthy subjects–A randomized, placebo-controlled, double-blind study. Fujioka S1, Hamazaki K, Itomura M, Huan M, Nishizawa H, Sawazaki S, Kitajima I, Hamazaki T.
- The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus. Duffy EM1, Meenagh GK, McMillan SA, Strain JJ, Hannigan BM, Bell AL.
- Do long-chain n-3 fatty acids reduce arterial stiffness? A meta-analysis of randomised controlled trials. Pase MP1, Grima NA, Sarris J.
- Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial. Vinding RK1,2, Stokholm J1, Sevelsted A1, Sejersen T1,2, Chawes BL1, Bønnelykke K1, Thorsen J1, Howe LD3, Krakauer M4, Bisgaard H5.
- Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers. Rhodes LE1, Shahbakhti H, Azurdia RM, Moison RM, Steenwinkel MJ, Homburg MI, Dean MP, McArdle F, Beijersbergen van Henegouwen GM, Epe B, Vink AA.
- Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Yurko-Mauro K1, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M; MIDAS Investigators.
- Xu ZZ, et al. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med. (2010)
- Lukiw WJ, et al. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest. (2005)
- Kliewer SA, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. (1995)
- Forman BM, et al. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. (1995)
- Maki KC, et al. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr Res. (2009)
- Dyerberg J, et al. Bioavailability of marine n-3 fatty acid formulations. Prostaglandins Leukot Essent Fatty Acids. (2010)
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